Over the past three months, targeted killings, bombings, extortion and threatening calls have victimised politicians and business owners, locals say.
Pakistan could join a blacklist of nations by February 2020 if significant efforts to fight money laundering and terror financing are not made.
Central Prison, built more than a century ago, has held members of the Tehreek-e-Taliban Pakistan, Lashkar-e-Islam and other insurgent groups.
Scores of suspects have already been arrested in the crackdown.
The number of cases in the country are surging at an alarming rate, officials say.
Police arrested Sohail Shahzad in connection with charges linked to 4 child slayings, and he will be tried under the country's anti-terrorism act.
Dacoits have conducted a range of activities for many years, including smuggling, gun-running, kidnapping for ransom and highway robberies. Authorities aim to wipe them out entirely.
The KP Control of Narcotics Substances Bill 2019 outlines the punishment -- sometimes capital punishment -- for trafficking, processing and transporting illegal drugs.
Smuggling, often used by extremists to finance their violent campaigns, is a serious threat to the economy and security, according to authorities.
Sindh police and other law enforcement agencies previously used to rely on conventional investigation techniques, which often yielded inferior or compromised results.