Police stopped the suicide bomber from entering a religious rally, preventing greater casualties.
Shehryar Mehsud, a TTP faction leader, was killed by a remote-controlled bomb in Afghanistan. Sheikh Khalid Haqqani, a member of the TTP's consultative council, was killed in late January.
The killing of the militant leaders behind the blast has weakened the insurgent outfit and bolstered residents' hopes for peace in Sindh.
Previously named as Abu Ibrahim al-Hashimi al-Quraishi, the terrorist leader is now said to be an Iraqi Turkmen named Amir Mohammed Abdul Rahman al-Mawli al-Salbi.
Maj. Gen. Qasem Soleimani led efforts to recruit vulnerable Shias in Pakistan and throughout the region, and used them on the battlefield in proxy wars at the behest of the Iranian regime.
Since its formation more than a decade ago, the TTP has been crumbling due to sustained military operations, the killing and capture of high-ranking leaders and internal fissures.
Members of the Afghan Taliban were among those killed in the suicide attack at a madrassa, and the bombing looks to be the result of infighting.
Terror attacks, launched by different militant, insurgent and violent sectarian groups, claimed 357 lives last year, a decline of 40% from a year earlier.
Vaccination campaigns have faced stubborn resistance with many refusing to have their children inoculated because of misinformation and conspiracy theories.
The Tehreek-e-Taliban Pakistan (TTP) massacre left more than 150 children and teachers dead.