Mohmand District militants blew up more than 120 educational institutions, including a college, in the worst years of terrorism before 2013.
The Baba Guru Nanak School of Science, Technology, Engineering, Art and Mathematics is expected to bolster computer skills for young Sikhs.
Critical thinking is essential for the children and could help them avoid extremism, say observers.
Education for girls in the Tirah Valley of Khyber District, once a distant dream, is now in full bloom amid the defeat of militants.
The initiative aims to help high school students learn critical thinking skills to reduce the effectiveness of extremist recruiters.
Youth who can't afford a higher education often are the targets of extremist recruiters, analysts say.
Improved security and stability in Khyber Pakhtunkhwa are opening the doors to a modern curriculum for all schoolchildren.
'This is a revolutionary step in a district affected by war,' an education leader said.
Six years after the Taliban forced the school to shutdown, a now safe environment in the city is allowing parents to send their children back.
The reforms aim to limit hate speech in madrassas and create new opportunities for students.